Brian Luke
Contributing Principal Investigator
- Address: iDN, Biozentrum I, Hanns-Dieter-Hüsch-Weg 15, 55128 Mainz
- Phone: +49 (0) 6131-39-21465
- Since 2017: Adjunct Director, Institute of Molecular Biology (IMB), Mainz
Professor, Faculty of Biology, Johannes Gutenberg University (JGU), Mainz - 2014–2017: Group Leader, IMB, Mainz
- 2009–2014: Group Leader, Centre for Molecular Biology (ZMBH), University of Heidelberg
- 2005–2009: Postdoctoral Researcher, Swiss Federal Institute of Technology in Lausanne (EPFL)
- 2005: Postdoctoral Researcher, Biochemistry, Swiss Federal Institute of Technology in Zurich (ETH)
Education:
- 2005: PhD in Biochemistry, ETH Zürich
- 1999: BSc in Biology, Queen’s University, Ontario
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Pires V, Lohner N, Wagner T, Paeschke K, Butter F, Luke B (2022)
RNA-DNA hybrids prevent resection at dysfunctional telomeres CellReports, (42):1120077 -
Wagner T, Pérez-Martínez L, Schellhaas R, Barrientos-Moreno M, Öztürk M, Prado F, Butter F and Luke B (2020)
Chromatin modifiers and recombination factors promote a telomere fold-back structure, that is lost during replicative senescence. PLOS Genet, 16:e1008603 -
Vydzhak O, Bender K, Klermund J, Busch A, Reimann S and Luke B (2020)
Checkpoint adaptation in recombination-deficient cells drives aneuploidy and resistance to genotoxic agents DNA Repair (Amst), 95:102939 -
Vydzhak O, Luke B and Schindler N (2020)
Non-coding RNAs at the Eukaryotic rDNA Locus: RNA-DNA Hybrids and Beyond J Mol Biol, 432:4287–4304 -
Schmidt TT, Sharma S, Reyes GX, Kolodziejczak A, Wagner T, Luke B, Hofer A, Chabes A and Hombauer H (2020)
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio Nucleic Acids Res -
Niehrs C and Luke B (2020)
Regulatory R-loops as facilitators of gene expression and genome stability Nat Rev Mol Cell Biol, 21:167–178 -
Kellner V and Luke B (2019)
Molecular and physiological consequences of faulty eukaryotic ribonucleotide excision repair EMBO J -
Lockhart A, Pires VB, Bento F, Kellner V, Luke-Glaser S, Yakoub G, Ulrich HD and Luke B (2019)
RNase H1 and H2 Are Differentially Regulated to Process RNA-DNA Hybrids Cell Rep, 29:2890-2900.e5