Christof Niehrs
Contributing Principal Investigator
- Address: IMB, Ackermannweg 4, 55128 Mainz
- Phone: +49 (0) 6131-39-21401
- Since 2020 and 2010-2015: Executive Director, Institute of Molecular Biology (IMB), Mainz
- Since 2010: Founding & Scientific Director, IMB, Mainz Professor, Faculty of Biology, Johannes Gutenberg University (JGU), Mainz
- Since 2000: Professor of Molecular Embryology, German Cancer Research Center (DKFZ), Heidelberg
- Since 1994: Head of Division "Molecular Embryology", DKFZ, Heidelberg
- 1990-1993: Postdoctoral Researcher, University of California, Los Angeles (UCLA)
Education:
- 1997: Habilitation in Biology, University of Heidelberg
- 1990: PhD in Biology, European Molecular Biology Laboratory (EMBL) and University of Heidelberg
- 1985: Diploma in Biochemistry, Free University of Berlin
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Kim M, Reinhard C, Niehrs C (2021)
A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling eLife, 10:e70885 -
Da Silva F, Zhang K, Pinson A, Fatti E, Wilsch-Bräuninger M, Herbst J, Vidal V, Schedl A, Huttner WB, Niehrs C (2021)
Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex EMBO J, e108041 -
Sun R, He L, Lee H, Glinka A, Andresen C, Hübschmann D, Jeremias I, Müller-Decker K, Pabst C and Niehrs C (2021)
RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia Cell Reports, 36(7):109559 -
Körtel N, Rücklé C, Zhou Y, Busch A, Hoch-Kraft P, Sutandy FXR, Haase J, Pradhan M, Musheev M, Ostareck D, Ostareck-Lederer A, Dieterich C, Hüttelmaier S, Niehrs C, Rausch O, Dominissini D, König J and Zarnack K (2021)
Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning Nucleic Acids Research -
Lehmann J, Thiele S, Baschant U, Rachner TD, Niehrs C, Hofbauer LC and Rauner M (2021)
Mice lacking DKK1 in T cells exhibit high bone mass and are protected from estrogen-deficiency-induced bone loss iScience, 24(3):102224 -
Lee H, Seidl C, Sun R, Glinka A and Niehrs C (2021)
R-spondins are BMP receptor antagonists in Xenopus early embryonic development. Nat Commun, 11:5570 -
Harshuk-Shabso S, Dressler H, Niehrs C, Aamar E and Enshell-Seijffers D (2020)
Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock Nat Commun, 11:5114 -
Leismann J, Spagnuolo M, Pradhan M, Wacheul L, Vu MA, Musheev M, Mier P, Andrade‐Navarro MA, Graille M, Niehrs C, Lafontaine DL and Roignant J (2020)
The 18S ribosomal RNA m6A methyltransferase Mettl5 is required for normal walking behavior in Drosophila EMBO Reports, 7 -
Musheev MU, Baumgärtner A, Krebs L and Niehrs C (2020)
The origin of genomic N6-methyl-deoxyadenosine in mammalian cells Nat Chem Biol, 16:630–634 -
Niehrs C and Calkhoven CF (2020)
Emerging Role of C/EBPβ and Epigenetic DNA Methylation in Ageing Trends Genet, 36:71–80 -
Chang L-S, Kim M, Glinka A, Reinhard C and Niehrs C (2020)
The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer eLife -
Niehrs C and Luke B (2020)
Regulatory R-loops as facilitators of gene expression and genome stability Nat Rev Mol Cell Biol, 21:167–178 -
Han D, Schomacher L, Schüle KM, Mallick M, Musheev MU, Karaulanov E, Krebs L, von Seggern A and Niehrs C (2019)
NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress eLife