René Ketting
Principal Investigator
- Project: Project 15.2, Project 5.1, Project 6.1, Project A.13
- Research Group
- Address: IMB, Ackermannweg 4, 55128 Mainz
- Phone: +49 (0) 6131-39-21470
"I am fascinated by the flexibility of gene regulatory networks and how they can adept to arising needs!"
- 2015-2017: Executive Director, Institute of Molecular Biology (IMB), Mainz
- Since 2012: Scientific Director, IMB, Mainz and Professor, Faculty of Biology, Johannes Gutenberg University Mainz (JGU)
- 2010-2013: Professor of Epigenetics in Development, University of Utrecht
- 2005-2012: Group Leader, Hubrecht Institute, Utrecht
- 2000-2004: Postdoctoral Researcher, Hubrecht Laboratory, Utrecht
Education:
- 2000: PhD in Molecular Biology, Netherlands Cancer Institute, Amsterdam
- 1994: Masters in Chemistry, University of Leiden
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Seistrup AS, Choppin M, Govind S, Feldmeyer B, Kever M, Karaulanov E, Séguret A, Karunanithi S, Almeida MV, Ketting RF, Foitzik S (2023)
Age- and caste-independent piRNAs in the germline and miRNA profiles linked to caste and fecundity in the ant Temnothorax rugatulus Molecular Ecology, 32(22):6027-6043 -
Dietz S, Almeida MV, Nischwitz E, Schreier J, Viceconte N, Fradera-Sola A, Renz C, Ceron-Noriega A, Ulrich H, Kappei D, Ketting RF, Butter F (2022)
The double-stranded DNA-binding proteins TEBP-1 and TEBP-2 form a telomeric complex with POT-1 Nature Communications, 12(1):1-20 -
Schreier J, Dietz S, Boermel M, Oorschot V, Seistrup AS, de Jesus Domingues AM, Bronkhorst AW, Nguyen DAH, Phillis S, Gleason EJ, L’Hernault SH, Phillips CM, Butter F & Ketting RF (2022)
Membrane-associated cytoplasmic granules carrying the Argonaute protein WAGO-3 enable paternal epigenetic inheritance in Caenorhabditis elegans Nature Cell Biology, 24:217–229 -
Volz A, Frei A, Kretschmer V, de Jesus Domingues AM, Ketting RF, Ueffing M, Boldt K, Krämer-Albers E, May-Simera HL (2021)
Bardet-Biedl syndrome proteins modulate the release of bioactive extracellular vesicles Nature Communications, 12(1):5671 -
Perez-Borrajero C, Podvalnaya N, Holleis K, Lichtenberger R, Karaulanov E, Simon B, Basquin J, Hennig J, Ketting RF, Falk S (2021)
Structural basis of PETISCO complex assembly during piRNA biogenesis in C. elegans Genes & Development, 35(17-18):1304-1323 -
Gudipati RK, Braun K, Gypas F, Hess D, Schreier J, Carl SH, Ketting RF, Großhans H (2021)
Protease-mediated processing of Argonaute proteins controls small RNA association Molecular Cell, 81(11):2388-2402 -
Redl S, de Jesus Domingues AM, Caspani E, Möckel S, Salvenmoser W, Mendez-Lago M and Ketting RF (2020)
Extensive nuclear gyration and pervasive non-genic transcription during primordial germ cell development in zebrafish. Development, 148:dev193060 -
Placentino M, Jesus Domingues AM, Schreier J, Dietz S, Hellmann S, Albuquerque BF, Butter F and Ketting RF (2020)
Intrinsically disordered protein PID-2 modulates Z granules and is required for heritable piRNA-induced silencing in the Caenorhabditis elegans embryo EMBO J, 40:e105280 -
Manage KI, Rogers AK, Wallis DC, Uebel CJ, Anderson DC, Nguyen DAH, Arca K, Brown KC, Cordeiro Rodrigues RJ, de Albuquerque BF, Ketting RF, Montgomery TA and Phillips CM (2020)
A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans eLife -
Cordeiro Rodrigues RJ, de Jesus Domingues AM, Hellmann S, Dietz S, de Albuquerque BFM, Renz C, Ulrich HD, Sarkies P, Butter F and Ketting RF (2019)
PETISCO is a novel protein complex required for 21U RNA biogenesis and embryonic viability Genes Dev, 13-14:857-870 -
Almeida MV, Andrade-Navarro MA, Ketting RF (2019)
Function and Evolution of Nematode RNAi Pathways Non-Coding RNA, 5(1):8