Claudia Keller Valsecchi
Principal Investigator
- Project: Project 17.2, Project A.07
- Research Group
- Address: IMB, Ackermannweg 4, 55128 Mainz
"Nature is by far more complex than the cells and model organisms in the laboratory environment. The gene expression field will learn a lot from looking at gene regulation in natural species in their actual environments."
- Since 2020: Group Leader, Institute of Molecular Biology (IMB), Mainz
- 2013–2020: Postdoctoral Researcher, Max Planck Institute of Immunobiology & Epigenetics, Freiburg
- 2012–2013: Postdoctoral Researcher, Friedrich Miescher Institute (FMI), Basel
Education:
- 2012: PhD in Biochemistry, Friedrich Miescher Institute (FMI), Basel
- 2008: MSc in Molecular Biology, Friedrich Miescher Institute (FMI), Basel
- 2007: BSc in Molecular Biology, Biozentrum, University of Basel
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Kalita AI, Keller Valsecchi CI (2025)
Dosage compensation in non-model insects – progress and perspectives Trends In Genetics, 41(1):76-98 -
Gibrán Fritz García JH, Keller Valsecchi CI, Basilicata MF (2024)
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks Open Biology, 14:240177 -
Kalita AI, Marois E, Kozielska M, Weissing FJ, Jaouen E, Möckel MM, Rühle F, Butter F, Basilicata MF, Keller Valsecchi CI (2023)
The sex-specific factor SOA controls dosage compensation in Anopheles mosquitos Nature, 623:175–182 -
Zimmer F, Basilicata MF, Keller Valsecchi CI (2023)
Transcription and replication meet the silent X chromosome territory Nature Structural & Molecular Biology, 30(8):1054-1056 -
Basilicata MF, Keller Valsecchi CI (2021)
The good, the bad, and the ugly: Evolutionary and pathological aspects of gene dosage alterations PLOS Genetics, 17(12):e1009906 -
Keller Valsecchi CI, Marois E, Basilicata MF, Georgiev P and Akhtar A (2021)
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila Life Science Alliance, 4(9):e202000996 -
Adrian-Kalchhauser I, Sultan SE, Shama L, Spence-Jones H, Tiso S, Keller Valsecchi CI and Weissing FJ (2021)
Inherited Gene Regulation Unifies Molecular Approaches to Nongenetic Inheritance: Response to Edelaar et al. Trends in Ecology & Evolution, 36(6):477 -
Adrian-Kalchhauser I, Sultan SE, Shama LNS, Spence-Jones H, Tiso S, Keller Valsecchi CI and Weissing FJ (2020)
Understanding 'Non-genetic' Inheritance: Insights from Molecular-Evolutionary Crosstalk Trends Ecol Evol, 35:1078–1089 -
Keller Valsecchi CI, Basilicata MF, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, Panhale A, Semplicio G, Manjunath V, Holz H, Dasmeh P and Akhtar A (2020)
RNA nucleation by MSL2 induces selective X chromosome compartmentalization Nature, 589:137–142 -
Pessoa Rodrigues C, Herman JS, Herquel B, Keller Valsecchi CI, Stehle T, Grün D and Akhtar A (2020)
Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate Sci Adv, 6:eaaz4815 -
Renschler G, Richard G, Keller Valsecchi CI, Toscano S, Arrigoni L, Ramírez F, Akhtar A (2019)
Hi-C guided assemblies reveal conserved regulatory topologies on X and autosomes despite extensive genome shuffling Genes Dev, 33:1591–1612 -
Keller Valsecchi CI, Basilicata MF, Semplicio G, Georgiev P, Gutierrez NM, Akhtar A (2018)
Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells Nature Communications, 9:3626 -
Basilicata MF, Bruel AL*, Semplicio G*, Keller Valsecchi CI*, Aktaş T*, Duffourd Y, Rumpf T, Morton J, Bache I, Szymanski WG, Gilissen C, Vanakker O, Õunap K, Mittler G, van der Burgt I, El Chehadeh S, Cho MT, Pfundt R, Tan TY, Kirchhoff M, Menten B, Vergult S, Lindstrom K, Reis A, Johnson DS, Fryer A, McKay V, Fisher RB, Thauvin-Robinet C, Francis D, Roscioli T, Pajusalu S, Radtke K, Ganesh J, Brunner HG, Wilson M, Faivre L, Kalscheuer VM, Thevenon J, Akhtar A, Study DDD (2018)
De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation Nature Genetics, 50:1442–1451